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Repairing DNA damage

Series
Cancer
Video Embed
Dr Ross Chapman studies the molecular events triggered by DNA damage detection, and why defects in these events lead to immune deficiency and cancer in humans.
GENOME INTEGRITY

Whilst controlled DNA breaks allow for our vast repertoire of antibodies, DNA damage happening out of context can lead to cancer or predisposition to cancer. Recent developments in personalised medicine exploit the DNA repair weaknesses of cancer cells to selectively kill them. A better understanding of the underlying mechanisms can help develop innovative and targeted therapies.

More in this series

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Cancer

Cleaning up misfolded proteins

Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases.
Previous
Cancer

Epigenetic modifications and cancer

Professor Skirmantas Kriaucionis aims to to elucidate the molecular function of DNA modifications in normal cells and cancer.
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Licence
Creative Commons Attribution-Non-Commercial-Share Alike 2.0 UK: England & Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Episode Information

Series
Cancer
People
Ross Chapman
Keywords
DNA
cancer
immune deficiency
antibodies
personalised medicine
Department: Nuffield Department of Clinical Medicine
Date Added: 28/04/2016
Duration: 00:07:00

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