Nuffield Department of Clinical Medicine

The Nuffield Department of Medicine (NDM) is a large multi-disciplinary Department that links high quality basic biological science with medical application. Led by Professor Peter Ratcliffe FRS, who is both an active researcher in cell biology and an active clinician, the Department employs in the region of 1000 scientific research staff working in a range of basic science and clinical disciplines. Our researchers contribute to the teaching of 450 medical students within Oxford University's Clinical School. Our base at the Headington Hospitals campus, Oxford, is now one of the largest centres for biomedical research in Europe with over £200M invested in capital projects and research infrastructure over the last decade. The rapidly growing campus provides a vibrant, highly interactive environment for research development. We are particularly committed to the career development of young scientists, including those from basic science as well as clinical backgrounds. In 2006 the Oxford University / Oxford Radcliffe Hospital Trust partnership successfully competed to be one of five UK Biomedical Research Centres. We played a leading role in this initiative, which provides a range of new opportunities for basic scientists to interact with clinical medical research, and for career development of clinician scientists. In addition to its Oxford base, the Department operates a number of major overseas programmes in tropical medicine and global health, with research units in Thailand, Laos, Vietnam and Kenya supporting activities at numerous sites in S-E Asia and Sub-Saharan Africa. We also operate extensive epidemiological and clinical trials networks throughout China, India and South America. In Oxford, NDM maintains research platforms across structural biology, protein biochemistry, genetics, genomics, proteomics, cell biology, chemical and genetic screening, imaging, bioinformatics, medical statistics, epidemiology, and clinical trials. Thematic research includes cancer biology, immunology, vaccinology, infectious diseases, gastroenterology, dermatology, diabetes and metabolic medicine, renal medicine, respiratory medicine, stroke medicine, and geratology.

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Title	Description	People	Date
Evolution and pathogenicity of viruses	Professor Peter Simmonds studies the epidemiology, evolution and emergence of a wide range of human pathogenic viruses.	Peter Simmonds	2 November, 2016
Introducing Mesh: The Global Health Network's Community Engagement Webspace	This webinar features introductions from Francois Van Loggerenberg, scientific lead at the Global Health Network, and community engagement consultant Georgia Bladon to the community engagement platform Mesh.	Francois van Loggerenberg, Georgia Blazon	31 October, 2016
X-rays for drug discovery	Professor Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins.	Frank von Delft	23 September, 2016
X-rays for drug discovery	Professor Frank von Delft works to ensure that X-ray structures can serve as a routine and predictive tool for generating novel chemistry for targeting proteins.	Frank von Delft	23 September, 2016
Method in the Motion	A unique evening combining a scientific talk with inspirational dance.	Irina Pulyakhina, Flux	14 July, 2016
Modelling bacterial drug resistance	Professor Ben Cooper from MORU in Thailand uses mathematical modelling and statistical techniques to help understand the dynamics of infectious disease and evaluate potential control measures.	Ben Cooper	1 July, 2016
Epidemiology and malaria elimination	Dr Richard Maude's work combines clinical studies, descriptive epidemiology and mathematical modelling of malaria in South and Southeast Asia.	Richard Maude	1 July, 2016
Modelling bacterial drug resistance	Professor Ben Cooper from MORU in Thailand uses mathematical modelling and statistical techniques to help understand the dynamics of infectious disease and evaluate potential control measures.	Ben Cooper	1 July, 2016
Epidemiology and malaria elimination	Dr Richard Maude's work combines clinical studies, descriptive epidemiology and mathematical modelling of malaria in South and Southeast Asia.	Richard Maude	1 July, 2016
Why data management matters	Naomi’s work focuses on supporting researchers to collect, clean and store research data.	Naomi Waithira	2 June, 2016
Malaria laboratory at MORU	Dr Kesinee Chotivanich's laboratory provides facilities and resources to researchers, students, and collaborators who are interested in tropical diseases, with the aim to improve patients’ care.	Kesinee Chotivanich	2 June, 2016
From information to structure	Dr Brian Marsden aims to make structural and chemical biology data accessible to non-experts, by providing computational resources including data management, sample tracking, in silico modelling support plus provision of public access to SGC data.	Brian Marsden	2 June, 2016
Why data management matters	Naomi’s work focuses on supporting researchers to collect, clean and store research data.	Naomi Waithira	2 June, 2016
Malaria laboratory at MORU	Dr Kesinee Chotivanich's laboratory provides facilities and resources to researchers, students, and collaborators who are interested in tropical diseases, with the aim to improve patients’ care.	Kesinee Chotivanich	2 June, 2016
From information to structure	Dr Brian Marsden aims to make structural and chemical biology data accessible to non-experts, by providing computational resources including data management, sample tracking, in silico modelling support plus provision of public access to SGC data.	Brian Marsden	2 June, 2016
Repairing DNA damage	Dr Ross Chapman studies the molecular events triggered by DNA damage detection, and why defects in these events lead to immune deficiency and cancer in humans.	Ross Chapman	28 April, 2016
Malaria in Kenya	There is a great need for better treatments for malaria and for a preventative malaria vaccine.	Philip Bejon	28 April, 2016
Microbiology in the tropics	The Cambodia Oxford Medical Research Unit (COMRU) is based in Siem Reap, northern Cambodia, which remains one of the poorest countries in South East Asia with extremely limited health services.	Paul Turner	28 April, 2016
Unravelling proteins	Dr Nicola Burgess-Brown heads the Biotechnology Group at the SGC, which generates proteins suitable for structural and functional studies.	Nicola Burgess-Brown	28 April, 2016
Targeting drug discovery	The development of new medicines is dependent on the identification of novel drug targets.	Kilian Huber	28 April, 2016
Microbiology research in SE Asia	Dr Direk Limmathurotsakul's research focuses on the epidemiology of melioidosis, a bacterial infection caused by Burkholderia pseudomallei.	Direk Limmathurotsakul	28 April, 2016
Tropical neonatology	Dr Claudia Turner heads the clinical research program at the Cambodia Oxford Medical Research Unit (COMRU), in collaboration with the Angkor Hospital for Children.	Claudia Turner	28 April, 2016
Global health informatics	Dr Chris Paton studies the use of open-source Electronic Health Records (EHR) software, online learning and mobile technology to improve healthcare delivery in low-resource settings.	Chris Paton	28 April, 2016
Dengue diagnosis and management	With 390 million infections occuring each year, dengue is the most important mosquito-borne viral infection, and no vaccine is currently available.	Bridget Wills	28 April, 2016
Understanding growth signals	Growth hormones and cytokines regulate the key physiological processes of growth and differentiation as well as responses to injury and infection.	Alex Bullock	28 April, 2016
Repairing DNA damage	Dr Ross Chapman studies the molecular events triggered by DNA damage detection, and why defects in these events lead to immune deficiency and cancer in humans.	Ross Chapman	28 April, 2016
Malaria in Kenya	There is a great need for better treatments for malaria and for a preventative malaria vaccine.	Philip Bejon	28 April, 2016
Microbiology in the tropics	The Cambodia Oxford Medical Research Unit (COMRU) is based in Siem Reap, northern Cambodia, which remains one of the poorest countries in South East Asia with extremely limited health services.	Paul Turner	28 April, 2016
Unravelling proteins	Dr Nicola Burgess-Brown heads the Biotechnology Group at the SGC, which generates proteins suitable for structural and functional studies.	Nicola Burgess-Brown	28 April, 2016
Targeting drug discovery	The development of new medicines is dependent on the identification of novel drug targets.	Kilian Huber	28 April, 2016
Microbiology research in SE Asia	Dr Direk Limmathurotsakul's research focuses on the epidemiology of melioidosis, a bacterial infection caused by Burkholderia pseudomallei.	Direk Limmathurotsakul	28 April, 2016
Tropical neonatology	Dr Claudia Turner heads the clinical research program at the Cambodia Oxford Medical Research Unit (COMRU), in collaboration with the Angkor Hospital for Children.	Claudia Turner	27 April, 2016
Global health informatics	Dr Chris Paton studies the use of open-source Electronic Health Records (EHR) software, online learning and mobile technology to improve healthcare delivery in low-resource settings.	Chris Paton	27 April, 2016
Dengue diagnosis and management	With 390 million infections occuring each year, dengue is the most important mosquito-borne viral infection, and no vaccine is currently available.	Bridget Wills	27 April, 2016
Understanding growth signals	Growth hormones and cytokines regulate the key physiological processes of growth and differentiation as well as responses to injury and infection.	Alex Bullock	27 April, 2016
Variation across the human genome: a tricky balancing act in human health and disease	Genetic variation can have opposing effects on human disease, where the benefits of a protective variant against one disease can increase the risk of another.	Mary Carrington	10 February, 2016
Malaria in pregnancy	In pregnant women, severe malaria is responsible for high maternal mortality, and uncomplicated malaria results in in high morbidity.	Rose McGready	4 February, 2016
Reducing HIV	Men who have sex with men (MSM) are a stigmatised group in Africa, but a predominant actor in the transmission of HIV.	Eduard Sanders	4 February, 2016
Cleaning up misfolded proteins	Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases.	John Christianson	4 February, 2016
Rare neurological disorders	Chorea-Acanthocytosis: ChAc is a rare progressive neurological disorder caused by mutations in a very complex gene.	Antonio Velayos-Baeza	4 February, 2016
Malaria in pregnancy	In pregnant women, severe malaria is responsible for high maternal mortality, and uncomplicated malaria results in in high morbidity.	Rose McGready	4 February, 2016
Reducing HIV	Men who have sex with men (MSM) are a stigmatised group in Africa, but a predominant actor in the transmission of HIV.	Eduard Sanders	4 February, 2016
Cleaning up misfolded proteins	Misfolded proteins can either create the loss of a cellular function, or escape degradation, causing aggregation diseases.	John Christianson	4 February, 2016
Rare neurological disorders	Chorea-Acanthocytosis: ChAc is a rare progressive neurological disorder caused by mutations in a very complex gene.	Antonio Velayos-Baeza	4 February, 2016
Targeting cancer mechanisms	Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion.	Robert Gilbert	7 January, 2016
Inflammation in disease	The main aim of Dr Xue's research is to understand the molecular and cellular mechanisms mediating inflammatory diseases, and to translate their findings into therapeutic concepts to treat these diseases.	Luzheng Xue	7 January, 2016
Computation and genetics	Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the right drug.	Zamin Iqbal	7 January, 2016
Targeting cancer mechanisms	Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion.	Robert Gilbert	7 January, 2016
Inflammation in disease	The main aim of Dr Xue's research is to understand the molecular and cellular mechanisms mediating inflammatory diseases, and to translate their findings into therapeutic concepts to treat these diseases.	Luzheng Xue	7 January, 2016
Computation and genetics	Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the right drug.	Zamin Iqbal	7 January, 2016
NDM Studentships	Every year, about 60 DPhil students start a life changing experience in the Nuffield Department of Medicine at the University of Oxford.	Robert Gilbert, Steinar Halldorsson, Sophie Andrews	2 December, 2015
The Evolution of the Genome	Computational and stastistical methods help us understand evolution as well as genetic disease.	Gerton Lunter	2 December, 2015
Tropical Immunology	Melioidosis is a neglected tropical disease, and a major infectious killer in South East Asia. Melioidosis particularly affects people with diabetes.	Susanna Dunachie	2 December, 2015
Sharing data to fight malaria	Over 250 Institutions participate in the effort of sharing data on the efficacy of antimalarial drugs, which involves standardising and re-analysing data.	Philippe Guérin	2 December, 2015
The Evolution of the Genome	Computational and stastistical methods help us understand evolution as well as genetic disease.	Gerton Lunter	2 December, 2015
Tropical Immunology	Melioidosis is a neglected tropical disease, and a major infectious killer in South East Asia. Melioidosis particularly affects people with diabetes.	Susanna Dunachie	2 December, 2015
Sharing data to fight malaria	Over 250 Institutions participate in the effort of sharing data on the efficacy of antimalarial drugs, which involves standardising and re-analysing data.	Philippe Guérin	2 December, 2015
Science in a crisis, fast-forwarding clinical research for Ebola	Professor Peter Horby's research focuses on epidemic diseases such as Ebola and bird flu, and crosses the disciplines of basic science, medical science and public health.	Peter Horby	2 December, 2015
Steinar Halldorsson	Every year, about 60 DPhil students start a life changing experience in the Nuffield Department of Medicine in Oxford.	Steinar Halldorsson	2 December, 2015
Sophie Andrews	Every year, about 60 DPhil students start a life changing experience in the Nuffield Department of Medicine in Oxford.	Sophie Andrews	2 December, 2015
The Heart and the Head, Part 5	Daniel Bulte, from the Department of Oncology, speaks about what happens when they discover an ‘incidental finding’.	Daniel Bulte	16 November, 2015
The Heart and the Head, Part 4	Portia Westall, from the Donnelly group at the WTCHG, speaks about how she thinks about music when working on DNA sequences.	Portia Westall	16 November, 2015
The Heart and the Head, Part 3	Erwan Atcheson, from the Jenner Institute, speaks about his time studying parasitic worms, and the worries that come with it.	Erwan Atcheson	16 November, 2015
The Heart and the Head, Part 2	Anna Fowler, from the Lunter group at the WTCHG, speaks about how the patterns around a close-call in the desert makes her think about her work.	Anna Fowler	16 November, 2015
The Heart and the Head, Part 1	Irina Pulyakhina, from the Julian Knight group at the WTCHG, speaks about her time helping a Masters student through an important presentation.	Irina Pulyakhina	16 November, 2015
The Heart and the Head, the full evening of science, storytelling, and music	An evening of storytelling and music where researchers from the Wellcome Trust Centre for Human Genetics, the Jenner Institute, and Cancer Research UK came together to tell stories about their lives as scientists, with live musical accompaniment.	Erwan Atcheson, Daniel Bulte, Anna Fowler, Brian Mackenwells, Irina Pulyakhina, Portia Westall, James Bell and the Half Moon All Stars	16 November, 2015
Artemisinin Resistance	Artemisinins are very poweful tools in the treatment of malaria, and the emerging loss of their activity has the potential to create a major public health problem.	Charlie Woodrow	5 October, 2015
The ethics of research	Identifying and addressing ethical issues are key to the success of any clinical trials, particularly when working with vulnerable populations.	Phaik Yeong Cheah	5 October, 2015
Science and Society	In settings with high level of poverty and over-stretched health services, researchers have even greater responsibilities to the communities and study participants.	Vicki Marsh	5 October, 2015
Melanoma	Melanoma or skin cancer is one of the fastest rising cancer types. When identified early, melanoma is relatively easy to cure, but once it starts to metastasise, it becomes very difficult to treat.	Colin Goding	5 October, 2015
Targeting epigenetics to treat cancer	Transcription is a tightly regulated process, where chemical modifications initiate the duplication of genetic material. This epigenetic process is often dysregulated in cancer, but it can be targeted with small molecule inhibitors.	Panagis Filippakopoulos	5 October, 2015
Artemisinin Resistance	Artemisinins are very poweful tools in the treatment of malaria, and the emerging loss of their activity has the potential to create a major public health problem.	Charlie Woodrow	5 October, 2015
The ethics of research	Identifying and addressing ethical issues are key to the success of any clinical trials, particularly when working with vulnerable populations.	Phaik Yeong Cheah	5 October, 2015
Science and Society	In settings with high level of poverty and over-stretched health services, researchers have even greater responsibilities to the communities and study participants.	Vicki Marsh	5 October, 2015
Melanoma	Melanoma or skin cancer is one of the fastest rising cancer types. When identified early, melanoma is relatively easy to cure, but once it starts to metastasise, it becomes very difficult to treat.	Colin Goding	5 October, 2015
Targeting epigenetics to treat cancer	Transcription is a tightly regulated process, where chemical modifications initiate the duplication of genetic material. This epigenetic process is often dysregulated in cancer, but it can be targeted with small molecule inhibitors.	Panagis Filippakopoulos	5 October, 2015
A deep breath in	Asthma and COPD (chronic obstructive pulmonary disease) are common conditions that affect the lives of many people.	Mona Bafadhel	28 July, 2015
Chemistry, epigenetics and drugs	Alteration of gene expression is fundamental to many diseases. A better understanding of how epigenetic proteins affect diseases provides a starting point for therapy development and the discovery of new drug.	Paul Brennan	28 July, 2015
The genetics of metabolic diseases	A missing step in a metabolic pathway leads to the build-up of toxic compounds, and the lack of materials essential for normal function.	Wyatt Yue	28 July, 2015
The economics of tropical diseases	Economics and health are interlinked in many ways, as seen in the vicious cycle between poverty and ill health.	Yoel Lubell	28 July, 2015
Getting the dose right	Too high a dose can result in toxicity and side-effects, too low a dose can cause the illness to come back and at worse develop resistance.	Joel Tarning	28 July, 2015
A deep breath in	Asthma and COPD (chronic obstructive pulmonary disease) are common conditions that affect the lives of many people.	Mona Bafadhel	28 July, 2015
Chemistry, epigenetics and drugs	Alteration of gene expression is fundamental to many diseases. A better understanding of how epigenetic proteins affect diseases provides a starting point for therapy development and the discovery of new drug.	Paul Brennan	28 July, 2015
The genetics of metabolic diseases	A missing step in a metabolic pathway leads to the build-up of toxic compounds, and the lack of materials essential for normal function.	Wyatt Yue	28 July, 2015
The economics of tropical diseases	Economics and health are interlinked in many ways, as seen in the vicious cycle between poverty and ill health.	Yoel Lubell	28 July, 2015
Getting the dose right	Too high a dose can result in toxicity and side-effects, too low a dose can cause the illness to come back and at worse develop resistance.	Joel Tarning	28 July, 2015
Enteric fever	Dr Christiane Dolecek speaks about the research on enteric fever she conducted in Vietman and Nepal	Christiane Dolecek	20 May, 2015
Enteric fever	Dr Christiane Dolecek speaks about the research on enteric fever she conducted in Vietman and Nepal.	Christiane Dolecek	20 May, 2015
Oxford University Clinical Research Unit Vietnam (OUCRU)	The Oxford University Clinical Research Unit (OUCRU) is a large-scale clinical and public health research unit based in Vietnam.	Guy Thwaites	13 April, 2015
Oxford University Clinical Research Unit Vietnam (OUCRU)	The Oxford University Clinical Research Unit (OUCRU) is a large-scale clinical and public health research unit based in Vietnam.	Guy Thwaites	13 April, 2015
Emerging Infectious Diseases	Professor Peter Horby is Senior Clinical Research Fellow. His research focusses on epidemic diseases such as Ebola and bird flu, and crosses the disciplines of basic science, medical science and public health.	Peter Horby	11 March, 2015
Emerging Infectious Diseases	Professor Peter Horby is Senior Clinical Research Fellow. His research focusses on epidemic diseases such as Ebola and bird flu, and crosses the disciplines of basic science, medical science and public health.	Peter Horby	11 March, 2015
Human Cancer Genetics	Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer.	Gareth Bond	11 March, 2015
Human Cancer Genetics	Dr Gareth Bond, Associate Member of the Ludwig Institute for Cancer Research, studies the influence of genetic variants on the origins, progression and treatment of human cancer.	Gareth Bond	11 March, 2015
Personalised Medicine	Dr Jenny Taylor is the Programme Director for the Genomic Medicine Theme, Wellcome Trust Centre for Human Genetics. Her research bridges the gap between genetics research and the use of its discoveries in diagnosis or treatment of medical conditions.	Jenny Taylor	9 February, 2015
Cancer predisposition and evolution	Identifying genes that increase the risk of bowel or other cancers allows us to offer preventative measures, such as removing tumours at an early stage. A better understanding of how and why cancers grow also helps develop improved treatments.	Ian Tomlinson	9 February, 2015
Cancer Informatics	Cancer research now generates huge amounts of data, and sophisticated computational tools are needed to answer biological questions. Making sense of this variability at molecular level will help us better tailor treatments to individual cancer patients.	Benjamin Schuster-Böckler	9 February, 2015
Biological imaging	Video microscopy aims to improve target discovery and drug development and to do so generates large volumes of data.	Jens Rittscher	9 February, 2015
Pharmacogenomics	Dr Sebastian Nijman develops new approaches to study signalling networks in cancer cells and uncover specific weaknesses, particularly in breast and lung cancer. This can be used to develop more effective drugs and to better guide treatment decisions.	Sebastian Nijman	9 February, 2015
Biological imaging	Video microscopy aims to improve target discovery and drug development and to do so generates large volumes of data.	Jens Rittscher	9 February, 2015

Nuffield Department of Clinical Medicine

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